养血清脑颗粒联合盐酸氟西汀治疗卒中后抑郁的临床研究

Yangxueqingnao Granule in Combination with Fluoxetine Hydrochloride for Post-Stroke Depression:A Clinical Study

目的:观察养血清脑颗粒联合盐酸氟西汀治疗卒中后抑郁的疗效。方法:68例卒中后抑郁患者随机分组后分别接受养血清脑颗粒+盐酸氟西汀联合治疗(治疗组)和单纯盐酸氟西汀治疗(对照组),疗程为8周;采用汉密尔顿抑郁量表(HAMD)进行评定。结果:在治疗8周后,治疗组的显效率(48.7%对47.1%)和总有效率(79.4%对76.5%)与对照组相比均无显著差异,HAMD总评分和各项目评分也无显著差异。两组之间的睡眠障碍项目评分在第2周时有显著差异(P<0.05),焦虑-抑郁情绪和躯体症状2个项目评分在第2周和第4周均有显著差异(P<0.05)。结论:养血清脑颗粒联合盐酸氟西汀治疗可改善卒中后抑郁的某些症状,优于单用盐酸氟西汀。

Objective： To observe the efficacy of Yangxueqingnao granule in combination with fluoxetine hydrochloride in the treatment of post-stroke depression （PSD）. Methods： Sixty-eight patients with PSD were randomized to receive either Yangxueqingnao granule plus fluoxetine hydrochloride （treatment group） or fluoxetine hydrochloride alone （control group）, and the duration of therapy was 8 weeks. The patients were evaluated with Hamilton Depression Scale （HAMD）. Results： As compared with the control group, both the obvious effective rate （48.7% uersus 47. 1%） and total effective rate （79.4%versus 76. 5%） after 8 weeks treatment in the treatment group had no significant differences. There were also no significant differences between the HAMD total score and each item score. There were significant differences in the item of sleep disorder score at week two between both groups （P 〈 0.05）; and there were significant differences between the item scores of anxiety-depression mood and somatic symptom at week2 and4 （P 〈0.05）. Conclusions： Yangxueqingnao granule in combination with fluoxetine hydrochloride therapy may improve some symptoms of PSD, which is superior to fluoxetine hydrochloride alone.