化疗同时补充氨基酸对老年非小细胞肺癌患者生活质量的影响

Effect of chemotherapy combined with amino acid on quality of life in elderly patients with non-small cell lung cancer

目的探讨老年非小细胞肺癌（non-small cell lung cancer，NSCLC）患者化疗同时补充氨基酸对其生活质量（qualityoflife，QOL）的影响。方法74例老年NSCLC患者随机分为试验组与对照组，统一采用长春瑞滨＋顺铂方案NP化疗3个周期，试验组化疗同时补充9复合氨基酸（9-AA）500ml／d，对照组单纯化疗。跟踪调查3个月，采用欧洲癌症研究与治疗组织（EORTC）生活质量核心问卷（QLQ-C30）和肺癌特异性模块QLQ-LC13调查随访患者化疗期间的QOL状态，并按WHO标准评价疗效。结果化疗后，试验组患者躯体功能、情绪功能、社会功能较对照组好转（Pd0．05），试验组有效率分别为87．8％、83．8％和77．0％对照组分别为77．0％、45．9％和45．9％）；试验组失眠、食欲丧失和疲倦症状较对照组减轻（P〈0．05），试验组各症状加重率分别为8．1％、5．4％和47．3%，对照组为17．6％、17．6％和59．5％。化疗前，两组患者以咳嗽、咯血、疼痛、呼吸困难为主要症状，化疗后均得到改善；试验组出现口舌疼痛症状比对照组患者少，分别占8．3％和18．4％（P〈0．05）。按WHO标准进行疗效评价显示，两组化疗疗效差异无统计学意义。结论化疗同时补充氨基酸可改善老年NSCLC化疗患者的QOL；500ml／d的氨基酸补充，安全性好。

Objective To investigate the effect of chemotherapy combined with amino acid on quality of life （QOL） in elderly patients with no,small cell lung cancer （NSCLC） . Methods Seventy-four elderly patients with NSCLC were divided randomly into experimental group and control group. The same NP （cisplatin ＋ vinorelbine） chemotherapy was carried out in all the 2 groups for 3 cycles. Except of chemotherapy, experimental group were treated with amino acid 500 ml/d in the seine time, while control group recieved chemotherapy only. After 3 monthes, the QOL was analyzed u-rag Chinese Version of European Organization for Research and Treatment of Cancer （EORTC） core questionnaire （QLQ-C30）and specific lung cancer module QLQLC13, and therapeutic effectiveness was evaluated according to WHO standard as well. Results After chemotherapy, the body function, mood function, social function were better in experimental group than in control group（all P〈0.05）, the effective rate was 87.8%, 83.8% and 77.0% in experimental group; 77.0%,45.9% and 45.9% in control group. Insomnia（8.1%）, suppressed appetite（5.4%）, weary（47.3%） were less serious in experimental group than in control group（17.6%, 17.6 % and 59.5%）（all P〈0.05）. The primary symptoms were cough, emptysis, thoracalgia and dyspnoea in both 2 groups before chemotherapy. All the symptoms were alleviated after chemotherapy. Some patients have side effects such as tongue pain, alopecie, hand and foot tingle. But the number of patients with tongue pain was less in experimental group （8.3% ） than in control group（18.4% ）. The chemotherapy effect had no difference by the WHO standard. Conclusions The QOL of elderly patients with NSCLC can be improved by chemotherapy combined with amino acid treatment, and the treatment with amino acid 500 ml/d is safety.