老年2型糖尿病患者胰岛素治疗后低血糖症发生频率的观察

Frequency of hypoglycemia in the elder with insulin-treated type 2 diabetes

目的观测老年胰岛素治疗的2型糖尿病患者低血糖症的频率。方法选取近三个月有低血糖症史的接受胰岛素治疗的2型糖尿病患者,分为老年组（≥60岁,240例）和非老年组（〈60岁,238例）,用动态血糖监测系统（CGMS）监测72小时,记录低血糖症（血糖≤3.9 mmol/L）的发生频率。结果血糖在2.8~3.9 mmol/L之间,老年组无症状低血糖症频率为27.38次/患者年,症状性低血糖症频率7.10次/患者年,两者差异有显著统计学意义（P〈0.01）;无症状低血糖症频率,老年组27.38次/患者年,非老年组11.25次/患者年,两组差异有统计学意义（P〈0.05）。结论在用胰岛素治疗的2型糖尿病患者中,老年患者无症状低血糖症频率明显高于症状性低血糖症频率,老年患者比非老年患者更易发生无症状低血糖症。

Objective Observing and recording the frequency of hypoglycemia in the elder with insulin-treated Type 2 diabetes. Methods Choosing the patients with insulin-treated Type 2 diabetes had a history of hypoglycemia in the past three months, were divided into the elderly group （ ≥60 years, n = 240） and the non-elderly group （ 〈 60 years, n = 238）, with CGMS monitor 72 hours, recording the frequency of hypoglycemia at blood gluoose level ≤ 3.9 mmol/L. Results In blood glucose between 2.8 - 3.9 mmool/L, in the elderly group frequency of asymptomatie hypoglycemia was 27.38 episodes per patient-year and symptomatic hypoglycemia was 7.10 episodes per patient-year, there was significant statistical difference （P 〈0.01） ; frequency of asymptomatie hypoglycemia, the elderly group was 27.38 episodes per ptient-year and the non-elderly group was 11.25 group group was 27.38 episodes per patient-year and the non-elderly group was 11.25 episodes per patient-year, there was statistical difference （ P 〈 0.05 ）. Conclusions In the patients with insulin-treated Type 2 diabetes, in the elderly patients the frequency of asymptomatie hypoglycemia was significantly higher than symptomatic hypoglycemia, the elderly patients were more easily asymptomatie hypoglycemia than the non-elderly patients.