东北地区患儿口服卡马西平后血药浓度与临床疗效分析

Analysis of clinical therapeutic effect and serum concentration carbamazepine for the children in northeast region

目的：监测服用卡马西平患儿血浆中卡马西平浓度，根据血药浓度数据，分析其与临床疗效的关系。方法：采用荧光偏振免疫法（FPIA）测定卡马西平血浆药物浓度；依据癫痫病的疗效评价标准对卡马西平的疗效进行评定；分析血药浓度、每日剂量（mg·kg^-1·d^-1）、日总剂量（mg·d^-1）与临床疗效关系。结果：卡马西平的血药质量浓度在4．0-12．0mg·L^-1。范围时，疗效较好。结论：临床用药时宜控制卡马西平的血药浓度最佳治疗范围为4．0～12．0mg·L^-1，临床疗效与血药浓度的相关性大于剂量（按公斤体质量计算）与血药浓度的相关性。

OBJECTIVE To determine carbamazepine in children serum after taking carbamazepine orally, and analysis the relationship between serum concentration and clinical therapeutic effect. METHODS To use FPIA for determination of carbamazepine in children serum to evaluate clinical therapeutic effect of carbamazepine to analyze the relationship among serum concentration,daily dose,total daily dose and clinical therapeutic effect. RESULTS The therapeutic effect was satisfactory when the serum concentration was in the range of 4. 0 - 12. 0 mg · L^-1. CONCLUSION Carbamazepine serum concentration shouled be controlled in the ranges of 4. 0- 12.0 mg·L^-1 as fat as possible in clinical medication,the dependability between clinical therapeutic effect and serum concentration is superior to the dependability between dose and serum concentration.