卵巢肿瘤中表皮生长因子受体和转化生长因子α的表达

Expression and significance of EGFR and TGF-α in ovarian neoplasm

研究表皮生长因子受体（EGFR）和转化生长因子α（TGF－α）与卵巢癌发生发展的关系．方法：用免疫组化ABC方法检测了EGFR，TGF－α，表皮生长因子（EGF）在72例卵巢肿瘤及正常卵巢组织中的表达情况．结果：TGF－α在卵巢癌中的检出率为71．05％，在良性肿瘤、交界性肿瘤和正常卵巢组织中的检出率分别为3．00％，58．33％％及41．67％，各组与卵巢癌组间均有显著差异（PM0．05）．EGFR在上述4组中的检出率分别为76．32％，40．00％，66．67％和41．67％，除交界性肿瘤组外，其余各组与卵巢癌组相比差异显著（P＜0．05）．在不同临床分期的卵巢癌中，TGF－α和EGFR的检出率分别为Ⅰ期：50％和50％，Ⅱa，b期：70．59％和76．47％，Ⅱc－Ⅳ期：84．62％和92．31％，可以看出TGF－α和EGFR在临床分期越晚的卵巢癌中，其检出率越高，且多数组间存在显著差异（P＜0．05）．EGF在上述各类组织中极少表达．结论：TGF－α和EGFR在卵巢肿瘤中有高水平的表达，且恶性程度越高，表达率越高，提示TGF－α／EGFR自分泌系统在卵巢癌的发生发展中起着重要的作用，而EGF／EGFR这一系统可能在卵巢癌中不发挥作用．

To study the relationship between epidermal growth factor receptor (EGFR), TGF-α,EGF and occurrence and development of ovarian cancer. Methods: Using ABC immunohistochemistry method.we investigated the expression of EGFR, TGF-α, EGF in 72 cases of ovarian neoplasm. Results: The positive rate of TGF-α in ovarian cancer, benign tumor, borderline tumor and normal ovarian tissue was 71. 05%,30. 00 %, 58. 33 % and 41. 6% respectively. There was significant difference between ovarian cancer group and other groups (P＜0. 05). The positive rate of EGFR in above groups was 76. 32%, 40. 00%, 66. 67% and 41. 67 % respectively. Except borderline tumor groyp, the significant difference was found between ovarian cancer and other groups(P＜0. 05). In different clinical phases of the ovarian cancer,the detectable rate of TGF-α and EGFR was that phase Ⅰ: 50. 00% and 50. 00%,phase Ⅱ a, b: 70. 59% and 76. 47%,phase Ⅱ c～Ⅳ:84. 62% and 92. 31 %, respectively. The higher the clinical phase was,the higher the positive rate was detected.Significant difference was found amongmost groups (P＜0. 05). Very low positive rate of EGF was detected in these kinds of tissues. Conclusions: TGF-α and EGFR autocrine mechanism play an important role in the occurrence and development of ovarian cancer, but EGF and EGFR doesn' t.