螺内酯对急性心肌梗死患者左心室重构的影响

Effect of spironolactone on the left ventricular remodeling in patients with acute myocardial infarction

目的探讨螺内酯对急性心肌梗死（AMI）患者左心室重构（LVRM）的影响。方法90例AMI患者随机分为螺内酯组（45例）和对照组（45例）。螺内酯组在常规治疗基础上加用螺内酯40mg／d；对照组常规治疗。两组患者AMI后7d、90d行超声心动图（UCG）检查，测定左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）及左心室射血分数（LVEF）。结果两组患者AMI后7d各UCG参数比较，差异无统计学意义（P〉0．05）；AMI后90d螺内酯组与对照组比较，LVEDD、LVESD明显降低（P〈0．05），LVEF明显升高（P〈0．05）。结论螺内酯可预防AMI患者LVRM的发生。

Objective To study the effect of spironolactone on the left ventricular remodeling （LVRM） in patients with acute myocardial infarction （AMI）. Methods 90 patients with AMI were randomly divided into spironolactone group（n = 45） and control group（ n = 45）. Spironolactone 40mg/d was administered in addition to the routine treatment for spironolactone group; the control group was received the routine treatment. All patients with AMI were examined left ventricular end systolic diameter （LVESD）, left ventricular end diastolic diameter （LVEDD） and LVEF on 7 days and 90 days by ultrasonic cardiogram（UCG）. Results Two groups patients with AMI in each UCG parameter had no significant difference on 7 days（P 〉 0.05） ; LVEDD, LVESD of spironolactone group on 90 days were significantly lower than that in control group（P〈 0.05） and LVEF of spironolactone group was significantly higher than that in control group（P 〈 0.05）. Conclusion Those findings indicate that in patients with AMI ,spironolactone may prevent LVRM.