原发性肝癌组织中MMP-9、p53的表达与临床病理之间的关系

Relationship between expression of MMP-9, p53 and the clinicpathological in primary hepatocarcinoma

目的研究原发性肝癌（PHC）组织中MMP-9、p53的表达，并探讨两者的相关性及临床意义。方法应用免疫组织化学法检测74例原发性肝癌组织中MMP-9、p53蛋白表达情况及微血管密度（MVD），并结合临床病理参数进行综合分析。结果MMP-9、p53的表达与原发性肝癌组织MVD、肿瘤大小、侵袭行为（血管侵犯情况和肿瘤包膜）等有关（P〈0．05）。MMP-9表达与p53表达之间呈正相关。结论MMP-9EM和p53均为反映PHC发生、进展及预后的重要指标。

Objective To investigate the expression of MMP-9, p53 protein in primary hepatocarcinoma （PHC） and the relationship between the clinicpathological in PHC. Methods The expression of MMP-9 and p53 in 74 cases with PHC and microvessel density（MVD） were detected by immunohistochemistry,the clinical pathological parameters were also analyzed. Results In hepato-cellular carcinoma,the expression of MMP-9 and p53 were closely related to MVD, tumor size, aggressive behavior （vascular metastasis and tumor envelope） （ P 〈 0.05 ）. The positive correlation was found between the expression of two factors in PHC. Conclusion MMP-9 and p53 might be important markers in the carcinogenesis, progression and prognosis of PHC.