摘要
目的:探讨红曲与葡萄籽原花青素(GSPE)混合剂对大鼠高脂血症的改善及对血清氧化性低密度脂蛋白的影响。方法:将60只大鼠按总胆固醇(TC)水平随机分为基础对照组、模型对照组及混合剂低、中、高三个剂量组,采用30万IUVD3/kg·d连续3d灌胃后,配合高脂饲料,复制大鼠动脉粥样硬化模型。空白对照组饲喂基础饲料,其余实验组饲喂高脂饲料;空白组及模型组灌胃蒸馏水,三个剂量组灌胃不同剂量混合剂,连续10周。在实验第2、4、6、8、10周测定血清总胆固醇(TC)、甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇(ox-LDL)、氧化性低密度脂蛋白及血清SOD、MDA、GSH-Px、T-AOC水平。结果:三个剂量组大鼠血清血脂水平(TC、TG、LDL-c)及ox-LDL明显降低,血清抗氧化能力(SOD、GSH-Px、T-AOC)提高,中、高剂量组效果优于低剂量组。结论:红曲及葡萄籽原花青素能缓解大鼠高脂血症,降低ox-LDL水平,提高机体抗氧化能力,延缓动脉粥样硬化的发生。
Objective： To observe the effects of liquid mixture of Monascus and grape seed procyanidins extract （GSPE） on levels of cholesterol and ox-LDL of atherosclerosis rats. Method： The models were developed by administering vitamin D3 and feeding high cholesterol diet. Serial assays of blood cholesterol, triglycerides, HDL-c, LDL-c, ox-LDL of the rats were performed and antioxidant statuses such as SOD, MDA, GSH-Px, and T-AOC were also detected. Results： Compared with those of rats in control group, serum TC, TG, HDL-c, LDL-c and ox-LDL levels of model rats significantly increase. Increases of TC, TG, LDL-c and ox-LDL levels of the rats are inhabited in three experimental group, and the antioxidant statuses are inproved significantly （p〈 0.05）. But there is no significant difference among HDL-c levels in these groups. Conclusions： The liquid mixture of Monascus and GSPE can delay the progress of the formation and development of atherosclerosis by various pathways.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2008年第7期420-423,共4页
Food Science
