芒果苷单钠盐的药效学实验研究

Experimental Study on the Pharmacology of Mangoferin Monosodium Salt

目的研究芒果苷单钠盐对呼吸系统的影响。方法通过腹腔注射给药,采用二氧化硫致咳法、酚红排泌法、乙酰胆碱-组胺引喘法和二甲苯致耳肿胀法研究芒果苷单钠盐镇咳、祛痰、平喘和抗炎的作用。结果芒果苷单钠盐显著延长二氧化硫所致小鼠咳嗽反应的潜伏期并减少咳嗽次数;显著增加小鼠呼吸道的酚红排泌量;显著延长乙酰胆碱-组胺诱发小鼠喘息的引喘潜伏期;显著抑制二甲苯所致小鼠耳廓肿胀。结论芒果苷单钠盐具有镇咳、祛痰、平喘和抗炎作用。

Objective To study the effect of mangoferin monosodium salt on respiratory system. Methods By abdominal injection, the methods of sulfur dioxide induced cough, phenolsulfonphthalein excretion test, histamine phosphate and acetylcholine induced asthma, and dimethy benzene induced swelling ear were adopted to observe the antiinflammatory antitussive, expectorant effects. Results Mangoferin monosodium salt was able to prolong cough latent period and decrease the frequency of cough significantly in miee resulted from sulfur dioxide, significantly increase phenolsulfonphthalein excretion quantity of tracheal in mice, prolong asthma latent period in mice induced by histamine phosphate and aeetylcholine,inhibit obviously the ear edema induced by dimethyl benzene in mice. Conclusion Mangoferin monosodium salt has antitussive,expectorant ,antiasthmatie and anti -inflammatory actions.