摘要
目的研究加拿大一枝黄花的镇痛、镇咳和祛痰作用及毒性,为正确对待这一生物入侵植物提供科学参考。方法采用热板法、扭体法观察镇痛作用,浓氨水诱咳法观察镇咳作用,酚红排泌法观察祛痰作用,最大耐受量法观察急性毒性。结果首次对国产加拿大一枝黄花进行了体内药理作用研究,发现加拿大一枝黄花提取物能显著延长醋酸致小鼠扭体潜伏期,减少扭体次数;但未明显提高热板法实验小鼠的痛阈值;能显著抑制浓氨水所致小鼠咳嗽潜伏期和咳嗽次数;显著增加小鼠气管的酚红排泌量;急性毒性实验表明加拿大一枝黄花提取物无明显毒性,既不引起小鼠死亡也不影响小鼠体重正常增加。结论加拿大一枝黄花具有明显的镇痛、镇咳和祛痰作用,无明显毒性。
Objective To study the analgesic, antitussive, expectorant effects and toxicity of Solidago canadensis L. Methods Hot - plate test, writhing test, the mouse cough test induced by ammonia, phenolsulfonphthalein excretion test and maximum tolerated dose test were used in this experiment. Results ESC（the extract of Solidago eanadensis L. ） markedly prolonged the writhing latent period and decreased the times of writhing of mice induced by ip acetic acid, while it had no obvious effect on the pain threshold value in hot plate test. ESC significantly prolonged the tussive latent period of mice, decreased the tussive times and increased phenolsulfonphthalein excretion quantity of trachea of mice. ESC was nontoxic according to the acute toxicity test. Conclusion ESC has obvious analgesic, antitussive and expectorant effects,and it is nontoxic.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第4期818-820,共3页
Lishizhen Medicine and Materia Medica Research
基金
上海交通大学PRP资助项目(No.11700803)
关键词
一枝黄花
镇痛
镇咳
祛痰
急性毒性
Solidago canadensis L.
Analgesic
Antitussive
Expectorant
Acute toxicity
