摘要
目的用探针药物研究黄芪对大鼠CYP450活性的影响。方法采用四氧嘧啶诱发糖尿病大鼠,正常大鼠为对照组,给予黄芪水提物诱导,通过HPLC检测探针药物的代谢率来评价各组CYP450 2E1活性。结果给药组动物血液中的氯唑沙宗的含量与模型组和空白组的含量无显著区别(P>0.05)。结论黄芪对大鼠CYP2E1活性无明显影响。
Objective To evaluate the effect of Huangqi on CYP2E1 activity of diabetic rats with probe drug. Methods Diabetic rat model was induced by alloxan. The rats were given the aqueous extracts of Huangqi orally for six days. The activity of CYP2Elwas evaluated by measuring chlorzoxazone, a drug probe for CYP2E1, and its metabolites were detected by HPLC. Results Huangqi had no effect on plasma concentration of cholrzoxazone, there was no significant difference when compared with control group and diabetic -model group（P 〉 0.05）. Conclusion Huangqi has no effect on CYP2E1 activity.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第4期965-966,共2页
Lishizhen Medicine and Materia Medica Research
