参芪扶正注射液对乳腺癌新辅助化疗患者细胞免疫功能的影响

Effects of Neoadjuvant Chemotherapy Combined with Shenqifuzheng Injection on Cell Immune Function for Patients with Breast Cancer

目的观察参芪扶正注射液对乳腺癌患者新辅助化疗细胞免疫功能的影响。方法73例乳腺癌患者随机分成单纯新辅助化疗组(Ⅰ组)35例,新辅助化疗联合参芪扶正注射液组(Ⅱ组)38例,治疗前后检测细胞免疫功能。结果Ⅰ组治疗后CD3,CD4,CD4/CD8,NK细胞明显下降,CD8明显上升(P<0.01);Ⅱ组CD3,CD4,CD4/CD8,NK细胞有所下降,CD8有所上升,但无统计学意义(P>0.05);Ⅱ组与Ⅰ组比较,CD3,CD4,NK细胞明显上升(P<0.05或P<0.01),CD8显著下降(P<0.01),CD4/CD8有所上升但无统计学意义(P>0.05)。结论新辅助化疗使乳腺癌患者细胞免疫功能明显下降,联合参芪扶正注射液治疗能使细胞免疫功能明显改善。

Objective To evaluate the effects of neoadjuvant chemotherapy combined with Shenqifuzheng Injection on cell im： mune function in patients with breast cancer. Methods 35 patients were enrolled in group Ⅰ ,treated with neoadjuvant chemotherapy only;38 patients were enrolled in group Ⅱ , treated with neoadjuvant chemotherapy combined with Shenqifuzheng injection. The peripheral blood samples were/evaluated with the flow eytometry for T lymphocyte subsets and NK cell before and after neoadujvant chemotherapy. Results The levels of CD3 , CD4, CD4/CD8, NK cell were signifianfly decreased and that of CD8 was increased compared with that before therapy in group Ⅰ respectively （ P 〈 0.01 ） ; The levels of CD3, CD4, CD4/CD8, NK cell were decreased compared with that before therapy in group Ⅱ respectively, but there had no significant difference（P 〉 0.05） ,and the level of CD8 was increased （P 〉 0.05 ） ;the levels of CD3, CD4, CD4/CD8, NK cell were increased （P 〉 0.05 or P 〈 0.01 ） and that of CD8 was decreased in group Ⅱ compared with group Ⅰ respectively （P 〈0.01 ）. Conclusion The cell immunity is further impaired by neoadujvant chemotherapy, neoadjuvant chemotherapy combined with Shenqifuzheng injection can enhance the cell immunity considerably.