灵芝孢子粉对兔移植性肿瘤生存期及外周血的影响

Effect of Spores of Ganoderma lucidum on Survival Time and Peripheral Blood Cell of Implanted Tumor Rabbit

目的探讨灵芝孢子粉对兔移植性肿瘤的生存期及外周血的影响。方法将成功接种荷VX2乳腺癌兔随机分为灵芝组和对照组,解剖死亡或结束时的兔子,用Kaplan-Meier进行生存曲线分析,Log Rank进行生存曲线显著性检验。比较外周血的变化。结果结束时灵芝组60%生存,中位生存期大于70d;而对照组只有20%生存,中位生存期为43d;两组生存期差别有统计学意义(P<0.05),兔最终死于远处转移。用药4周后灵芝组的白细胞(17.45×109/L±5.74×109/L)比对照组(11.20×109/L±2.81×109/L)明显升高(P<0.05)。血红蛋白含量和血小板无明显变化(P>0.05)。结论灵芝孢子粉能够延长荷VX2乳腺癌兔的生存期,能提高白细胞。

Objective To study the effect of spores of Ganoderma lucidum on survival time and peripheral blood cell of implanted tumor rabbit . Methods The rabbits with transplantable VX2 carcinoma were randomly divided into spores of Ganoderma Lucidum treatment group （10 cases）and control group （10 cases）. Survival rate curves were analyzed by Kaplan- Meier method. Difference between survival rate curves was tested by Log Rank test and the changes of Peripheral blood cell were compared between the two groups. Results The survival rate and median survival time in treatment group and the control group were 60% 〉 70day and 20% ,43day respectively. There was a significant difference in survival curves. Rabbits were died from distant metastasis. The treatment course lasted 4weeks. The leukocyte count（WBC） of animals in treatment group were（ 17.45×10^9/L ± 5.74 ×10^9/L）, which was significantly more than that in control group （ 11.20×10^9/L ±2.81 ×10^9/L）. There has no marked changes in hemoglobin（Hb） and platelet（PLT） （ P 〉 0.05 ）. Conclusion Spores of Ganoderma Lucidum can prolong the animals＇survival time and inerease leukocyte count（WBC）.