慢性阻塞性肺疾病（COPD）加重期支气管肺泡灌洗疗效观察

Observation on the Curative Effect of BAL in the Treatment of COPD in Exacerbation Period

目的评价支气管肺泡灌洗治疗术在COPD加重期的疗效。方法67例患者分为治疗组（37例）和对照组（30例）两组常规治疗相同，治疗组配合用纤维支气管镜进行支气管肺泡灌洗治疗。观察临床症状体征及治疗组在支气管肺泡灌洗前后的24h血气分析指标，7天后评估疗效。结果 治疗组和对照组的临床症状体征改善有效率分别为94．59％和74．17％（P〈0．05），并且在治疗组里经配合用支气管肺泡灌洗前后24h血气分析指标也有明显改善（P〈0．05）。结论配合支气管肺泡灌洗是治疗COPD加重期的有效方法。掌握好适应症，及时清除呼吸道痰液及炎症，是治疗成功的关键。

Objective To evaluate the curative effect of bronchoalceolar lavage （BAL） in the treatment of chronic obstructive pulmonary disease （COPD） of exacerbation period. Method A total of 67 cases patients were divided into treatment group of 37 cases and control group of 30 cases. The regular treatment in two groups is the same and BAL was added through fiberoptic bronchoscope in treatment group. The clinical symptoms and sign and blood gas analysis indexes 24 hours before or after BAL in treatment group were observed and the curative effect had been evaluated 7 days later. Result The effective rates in the improvement of clinical symptoms and sign in treatment group and control group were respectively 94.59% and 74.17% （ P 〈 0.05）. Blood gas analysis indexes 24 hours before or after BAL had obviously improved （P 〈 0. 05） Conclusion Combining with the BAL is an effective method for the treatment of COPD in exacerbation period. Mastering the indications and getting rid of the sputum of respiratory tract and inflammation in time are necessary for the successful treatment.