药代动力学建模的人工神经网络新方法

Artificial neural network:a new method in pharmacokinetic modeling

人工神经网络(ANN)在药代动力学领域主要用于血药浓度预测、药物结构和药代动力学定量关系、体内体外相关关系研究,群体药物动力学数据分析、药代动力学-药效动力学统一模型研究等。本文就ANN的基本理论及其在药代动力学研究的应用作简要综述。

Artificial neural network （ANN） is applied in the pharmacokinetics, such as the prediction of drug blood levels , quantitative structure-pharmacokinetic relationships, in vitro - in vivo correlation,population pharmacokinetic data analysis and pharmacokinetic - pharmacodynamic link models analysis. In this paper, the basic theory and the application in pharmacokinetics of ANN is reviewed.