用三联法根除幽门螺杆菌失败后的补救方案

Rescue regimen after Helicobacter pylori eradication failure with triple therapy

目的探讨三联疗法(质子泵抑制剂+阿莫西林+克拉霉素)根除幽门螺杆菌(HP)治疗失败后的补救方案。方法将95名HP感染且三联疗法根除HP治疗失败的患者,随机分为试验组与对照组,并分别用新三联法(质子泵抑制剂+阿莫西林+左氧氟沙星)与四联法(质子泵抑制剂+铋剂+四环素+甲硝唑)比较,在治疗结束时和结束后4周,检测HP,并评价耐受性。结果在HP根除率和耐受性,试验组优于对照组。结论以左氧氟沙星为基础的新三联方案是有效的补救方案,优于四联方案。

Objective To investigate the rescue regimens after failed of Helicobacter pylori （HP）eradication with standard triple therapy. Methotis Ninety-five patients who infected HP with triple therapy （PPI ＋ amoxicillin ＋ clarithromycin）failed were random devided into trial group （ PPI ＋ levofloxacin ＋ amoxicillin） and control group （ quadruple therapy） ,then the rate of HP eradication was evaluated, the adverce reaction was evaluated after the end of treatment . Results Trial group was better than control group in rate of HP eradication, trial group was less than control group in adverse reaction. Conclusion After HP eradication failure, levofloxacin-based rescue regimen is more effective and tolerated better than the generally recommended quadruple therapy.