补肾活血方对膝骨关节炎蛋白聚糖和Ⅱ型胶原表达的影响

Effect of Bushen Huoxue Prescription on the Expression of Proteoglycan and Coliagen TypeⅡ in Knee Osteaoarthritis

目的:观察补肾活血方对膝骨关节炎(OA)蛋白聚糖和Ⅱ型胶原表达的影响。方法:将60例患者随机分2组各30例,治疗组予补肾活血方治疗,对照组予西乐葆治疗,观察2组治疗后血清蛋白聚糖与Ⅱ型胶原表达情况。结果:治疗后2组膝关节功能评分较治疗前均有明显提高(P<0.01);治疗后2组间比较,差异无显著性意义(P>0.05)。治疗后3月,治疗组蛋白聚糖、Ⅱ型胶原表达明显下降,与本组治疗前及对照组同时段比较,差异均有非常显著性意义(P<0.01);治疗后6月,2组蛋白聚糖、Ⅱ型胶原表达均明显下降,与治疗前比较,差异均有非常显著性意义(P<0.01)。结论:补肾活血中药能促进OA患者软骨蛋白聚糖和Ⅱ型胶原的表达,对膝OA关节软骨有保护作用。

Objective:To observe the effect of Bushen Huoxue Prescription(BHP)on protenglycan(PG)and collagen typeⅡ(CTⅡ) in knee osteoarthritis(OA).Methods:Sixty patients were equally randomized into 2 groups:the treatment group received BHP,and the control group was given Celecoxib.The expression of serum PG and CTⅡ was observed in the two groups after treatment.Results:The scores of knee joint function were increased in the two groups after treatment(P<0.01 compared with those before treatment),but the differences being insignificant between the two groups(P>0.05).Three mantbe after treat- ment,the expression levels of PG and CTⅡ were decreased in the treatment group(P<0.01 compared with those before treatment and in the control group).Six months after treat- ment,the expression levels of PG and CTⅡwere decreased in the two groups(P<0.01 compared with those before treatment).Conclusion:BHP has protective effect on knee os- teoarthritis,and can promote the expression of PG and CTⅡ in patients with knee OA.