结肠康结肠定位微丸制备工艺研究

Study on Colon Positioning Prepare Technics of Jie Changkang Pellets

目的:针对溃疡性结肠炎,以苦参提取物为原料,研究结肠康微丸的制备工艺。方法:在微丸制备工艺的研究中,运用锅包衣法,以微丸外观、水分含量、溶解时限、休止角和堆密度为指标,对微丸制备辅料的种类和用量进行考察,筛选出微丸最佳制备工艺条件。结果:微丸制备选择以100%羧甲基淀粉钠作为赋形剂,50%乙醇为润湿剂,包衣转速45 r/m in,进风温度30℃,采用泛制法制备微丸。结论:该微丸制备重复性良好,工艺稳定,可行。

Objective： In view of Ulcerative Colitis, we use Oxymatrine extract as raw materials to study on colon Positioning Prepare Technics of Jie Changkang pellets. Methods： In the research, we use Pan coating method, based on the determination target of pellets outward appearance, moisture content, dissolved time, the rest angle and bulk density to decide the best colon Positioning Prepare Technics conditions. Results： Pellets molding choose to 100% sodium carboxymethyl starch as excipients, 50% ethanol for wetting agent, coating speed of 45 rpm, intake air temperature 30℃, prepared by the Pan - system pellets. Conclusion ： The best processed condition that elects is steady and feasible.