摘要
调节性T细胞是当前免疫学研究的热点之一。人类天然调节性T细胞相当于小鼠CD4^+CD25^+T细胞,是正常发生于胸腺的特定细胞系,在体外对TCR刺激无反应,能抑制自身反应性T细胞,维持免疫的自身耐受。但在表面表型、分离方法和一些生物学特性方面存在差别。有证据提示,一些与自身免疫和变态反应有关的皮肤病存在调节性T细胞的功能障碍,应进一步研究。
Regulatory T cells are now a focus of immunology research. Human naturally occurring regulatory T cells derive from thymus. They have no response to T cell receptors in vitro, could suppress autoreactive T cells and maintain autoimmune tolerance. They are very similar to mouse CD4^+CD25^+ T cells in many aspects except in surface phenotype, isolation methods, and some biological characteristics. There is accumulating evidence that regulatory T cells have functional deficiencies in some cutaneous disorders related to autoimmunity and allergy. This is a domain that deserves further study.
出处
《国际皮肤性病学杂志》
2008年第4期232-234,共3页
International Journal of Dermatology and Venereology