人类天然调节性T细胞与皮肤病

Human naturally occurring regulatory T cells and dermatologic diseases

调节性T细胞是当前免疫学研究的热点之一。人类天然调节性T细胞相当于小鼠CD4^＋CD25^＋T细胞，是正常发生于胸腺的特定细胞系，在体外对TCR刺激无反应，能抑制自身反应性T细胞，维持免疫的自身耐受。但在表面表型、分离方法和一些生物学特性方面存在差别。有证据提示，一些与自身免疫和变态反应有关的皮肤病存在调节性T细胞的功能障碍，应进一步研究。

Regulatory T cells are now a focus of immunology research. Human naturally occurring regulatory T cells derive from thymus. They have no response to T cell receptors in vitro, could suppress autoreactive T cells and maintain autoimmune tolerance. They are very similar to mouse CD4^＋CD25^＋ T cells in many aspects except in surface phenotype, isolation methods, and some biological characteristics. There is accumulating evidence that regulatory T cells have functional deficiencies in some cutaneous disorders related to autoimmunity and allergy. This is a domain that deserves further study.