可显影固体栓塞剂硫酸钡海藻酸钠微球的研制

Preparation of X-ray developable alginate-barium sulfate microspheres as material for embolic agent

目的:研制可显影固体栓塞剂硫酸钡海藻酸钠微球。方法:采用乳化-离子交联法制备微球,正交设计优化工艺,并考察微球的粒径、形态、分布、稳定性、悬浮性、包封率及X线显影性等理化特性。结果:微球平均粒径为(53.08±32.72)μm,分散良好,形态圆整;微球100℃水浴加热2h、-4℃冰冻24h、37℃振摇24h、钴60(10kGy)照射0.5h各组的破损率分别为(2.0±1.1)%、(86.0±19.2)%、(39.0±14.7)%和(10.3±3.2)%;0.25%海藻酸钠微球混悬液的沉降体积比为(0.92±0.018);硫酸钡投料量为2.0g时包封率为(69.2±13.2)%,且显影效果佳。结论:海藻酸钠、壳聚糖可作为硫酸钡微球的包封材料,乳化-离子交联法适用于此微球的制备。

Objective：To prepare an X-ray developable alginate barium sulfate microspheres as material for embolic agent. Methods： The emulsification internal gelation technique was used to prepare alginate microspheres and the orthogonal design was adopted to optimize the technique. The diameter, shape, dispersibility, stability, suspension property, coating ratio and developability under X-ray of the microspheres were examined. Results： The average diameter of the microspheres was （53.08± 32.72）μm; they were well distributed and had a round shape. The ratio of the destroyed micros pheres was （2.0± 1.1 ）% after heated at 100℃for 2 h,（86.0±19.2）% after frozen at -4℃ for 24 h,（39.0±14. 7）% after vibrated at 37℃ for 24 h,and （10. 3±3.2）% after irradiated with 60^Co（10kGy）for 0.5 h. The ratio of sedimentation volume in 0.25% suspension of sodium alginate microspheres was （0.92±0.0]8）. The coating rate was （69.2± 13.2） % when the feeding amount of barium sulfate was 2.0 g,and the result of X-ray development was good. Conclusion： Alginate-chitosan can be used for the preparation of barium sulfate microspheres; and the emulsification internal gelation technique can prepare the microspheres with good dispersibility and shape.