肿瘤热疗的区域多点温控研究

Multipoint Temperature Control of Hyperthermia Lesion Region

目的:温度控制是肿瘤热疗过程中至关重要的环节,本文结合多点测温系统和射频肿瘤消融系统,以提高肿瘤热疗的疗效及安全性为出发点,探讨肿瘤热疗的单点温控以及区域多点温控的方法和策略。方法:分析并综合模糊控制和PID控制算法的优缺点,提出了性能更好的模糊-改进PID温控方法,用于对热疗进行单点温控,再利用区域多点温控策略实现区域多点温控。结果:离体猪肝实验表明,模糊控制的动态特性较好,而稳态特性较差;改进PID控制的稳态特性较好,而动态特性较差;模糊—改进PID控制方法综合了模糊控制和改进PID控制的优点,增强了温度控制的动态性能和稳态性能;区域多点温控策略能很好地实现区域实时温度控制。结论:本文提出的模糊—改进PID控制方法和区域多点温控策略能进一步改善热疗系统的性能。

Objective： Temperature control is very important for hyperthermia. In order to improve the cure effect and the security of operation, this paper discusses the single-point and multi-point temperature control of hyperthermia on the basis of the multipoint thermometer and Radioffequency Ablation system. Method： After synthesizing the characteristic of Fuzzy and PID controller, we present a more useful Fuzzy-Improved PID method. The mulfipoint temperature control strategy is used to choose the appropriate control point. Then, Fuzzy and improved PID methods are united to control the temperature of this correspond ing point. Result： Pig liver hyperthermia experiments in vitro shows that Fuzzy method is good at dynamic state, but bad at steady state, while PID method performs well in steady state, but bad at dynamic state. Fuzzy-Improved PID method performs very well in both dynamic and steady state. Moreover, the multipoint temperature control strategy can achieve to control tern perature of lesion region in real-time. Conclusion： The proposed temperature control method used in this work can ira- prove the performance of Hyperthermia.