期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

皮肤鳞状细胞癌中人乳头瘤病毒的检测 被引量：1

Detection of mucosal human papillomavirus in lesions of cutaneous squamous cell carcinoma
下载PDF
导出
摘要 目的:检测皮肤鳞状细胞癌(SCC)皮损中的人乳头瘤病毒(HPV)并探讨其在SCC发病中的作用。方法:用原位杂交(ISH)、聚合酶链反应技术(PCR)检测SCC患者43例,健康者28例标本组织切片中的HPV6、11、16、18、31、33。结果:43例SCC中有2例肢端部位皮损呈HPVDNA阳性,检出类型为HPV16和HPV33。其中1例标本中HPV16和HPV33同时阳性。对照组全部为阴性。结论:HPV16等6种黏膜型HPV可能与肢端以外SCC的发生无相关性,而与肢端部位SCC可能有关联性。 Objective： To investigate the presence of HPV DNA and the different mucosal HPV genotypes in squamous cell carcinoma （SCC）, and to explore the role of HPV in the pathegenesis of SCC. Methods： HPV subtype 6,11,16,18,31,33 in specimens from 43 SCC （16 women and 27 men） and 28 controls were detected by in situ hybridization （ISH） and PCR. Results： HPV DNA was positive in 2 SCC specimens obtained in extremities （subtype 16, 33）. Out of the two specimens both HPV16 and HPV 33 were positive. All the control specimens were negative. Conchusion： The six HPV subtypes tested are not associated with cutaneous SCC,except for the two specimens obtained in extremities.
作者 马冬梅 卢宪梅 周桂芝 陈学超
机构地区 山东省皮肤病性病防治研究所
出处 《中国麻风皮肤病杂志》 2008年第7期526-528,共3页 China Journal of Leprosy and Skin Diseases
基金 山东省科技攻关计划资助项目(2004GG3202015)
关键词 皮肤鳞状细胞癌 人乳头瘤病毒 原位杂交 聚合酶链反应 squarnous cell carcinoma human papillomavirus in situ hybridization （ISH） PCR
分类号 R739.5 [医药卫生—肿瘤] R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献10

  • 1Yamamoto A, Kumakura S, Uchida M, et al. Immortalization of normal human embryonic fibroblasts by introduction of either the human papillomavirus type 16 E6 or E7 gene alone. Int J Cancer 2003; 106(3) :301 - 309.
  • 2Antonsson A, Forslund O, Ekberg H, et al. The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses. J Vital 2000;74(24):11636- 11641.
  • 3Antonsson A, Karanfilovska S, Lindqvist PG, et al. General acquisition of human skin papillomavirus infections occurs in early infancy. J Clin Microbiol 2003;41:2509-2514.
  • 4Forslund O, Nordin P, Hansson BG. Mucosal human papillomavirus types in squamous cell carcinomas of the uterine cervix and subsequently on fingers. Br J Dermatol 2000; 142(6) : 1148 - 1153.
  • 5Forslund O, Lindelof B, Hradil E, et al. High prevalence of cutaneous human papillomavirus DNA on the top of skin tumors but not in "Stripped" biopsies from the same tumors. J Invest Dermatol 2004; 123(2) :388 - 394.
  • 6Forslund O, Ly H, Reid C, et al. A broad spectrum of human papillomavirus types is present in the skin of australian patients with non - melanoma skin cancers and solar keratosis. Br J Dermatol 2003; 149(1):64-73.
  • 7Meyer T, Arndt R, Nindl I, et al. Association of human papillomavirus infections with cutaneous tumors in immunosuppressed patients. Transpl Int 2003;16(3):146- 153.
  • 8Harwood CA, Proby CM, McGregor JM, et al. Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series. J Am Acad Dermatol 2006;54(2):290-300.
  • 9Harwood CA, Surentheran T, McGregor JM, et al. Human papillomavirus infection and non- melanoma skin cancer in immunosup- pressed and immunocompetent individuals. J Med Viral 2000; 61 (3) :289 - 297.
  • 10Weissenbom SJ, Nindl I, Purdie K, et al. Human papillomavirus - DNA loads in actinic keratoses exceed those in non- melanoma skin cancers. J Invest Dermatol 2005; 125(1) :93 - 97.

同被引文献7

  • 1VASILJEVIC N,HAZARD K,DILLNER J,et al.Four novel human betapapillomaviruses of species2 preferentially found in actinic keratosis[J].J Gen Virol,2008,89(Pt 10):2467-2474.
  • 2DE KONING M N,WEISSENBORN S J,ABENI D,et al.Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma[J].J Gen Virol,2009,90 (Pt7):1611-1621.
  • 3TUROWSKI C B,ROSS A S,CUSACK C A.Human papillomavirus-associated squamous cell carcinoma of the nail bed in African-American patients[J].Int J Dermatol,2009,48(2):117-120.
  • 4ZARAVINOS A,KANELLOU P,SPANDIDOS D A.Viral DNA detection and RAS mutations in actinic keratosis and nonmelanoma skin cancers[J].Br J Dermatol,2010,162(2):325-331.
  • 5PLASMEIJER E I,NEALE R E,DE KONING M N,et al.Persistence of betapapillomavirus infections as a risk factor for actinic keratoses,precursor to cutaneous squamous cell carcinoma[J].Cancer Res,2009,69(23):8926-8931.
  • 6ORTH G.Genetics of epidermodysplasia verruciformis:Insights into host defense against papillomaviruses[J].Semin Immunol,2006,18 (6):362-374.
  • 7ALOTAIBI L,PROVOST N,GAGNON S,et al.Diversity of cutaneous human papillomavirus types in individuals with and without skin lesion[J].J Clin Virol,2006,36(2):133-140.

引证文献1

二级引证文献4

中国麻风皮肤病杂志
2008年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部