抗环瓜氨酸肽（CCP）抗体检测在诊断类风湿性关节炎中的应用

Application on CCP Antibody Testing in RA Diagnosis

目的：探讨抗环瓜氨酸肽（CCP）抗体对类风湿性关节炎（RA）的诊断价值。方法：收集类风湿性关节炎患者血清65例，健康人血清35例，检测血清抗CCP抗体、类风湿因子（RF），并将检测结果作对比分析。结果：65例RA中，CCP阳性率67．7％（44／65），RF阳性率70．8％（46／65）；35例健康人中CCP阳性率2．9％（1／35），RF阳性率17．0％（6／35）。RA组与健康人组比较：抗CCP抗体阳性率及RF阳性率均有显著性差异（P〈0．05）。结论：抗CCP抗体对诊断RA具有较好的敏感性，是RA一个较好的辅助诊断指标。

Objective： To explore the diagnosis value of CCP antibody in rheumatoid arthritis. Methods： By collecting 65 cases of serum of those affected with RA and 35 cases of healthy people＇s serum, we test CCP and RF to each one then make a comprason. Results： In the 65 cases of RA, the positive rates of CCP and RF are 67. 7% （44/65） and 70. 8% （46/65） respectively; in the 35 cases of healthy people, the positive rates of CCP and RF are 2.9% （1/35） and 17.0% （6/35）. There are obvious diffrences between the two groups （P〈0. 05）. Conclusion： CCP antibody is sensitive to the RA diagnosis and it is a good indicator.