血清同型半胱氨酸测定在2型糖尿病患者肾损害中的探讨

Exploration on the Determination of the Serum Homocysteine in Type 2 Diabetes with Renal Damage

目的：探讨2型糖尿病患者血清中同型半胱氨酸（Hcy）的含量，以了解肾损害的情况。方法：将88例2型糖尿病患者根据尿清蛋白排泄率（UAER）的不同分为单纯性糖尿病组、早期糖尿病肾病组和临床糖尿病肾病组并以40例健康者作为对照，采用循环酶法测定血清中Hcy的含量。结果：早期糖尿病肾病组和临床糖尿病肾病组与单纯糖尿病组和健康对照组比较Hcy含量明显偏高有统计学意义（P〈0．05），且临床糖尿病肾病组显著高于早期糖尿病肾病组（P〈0．05），单纯性糖尿病及健康对照组血清Hcy的含量无显著性差异（p〉0．05）。结论：血清Hcy水平的升高对提示2型糖尿病患者发生肾损害有一定临床上意义。

Objective： To explore the quantity of serum homocysteine in type 2 diabetes and find out the situration of renal damage. Methods： According to UAER, 88 cases of type 2 diabetes can be divided into 3 groups： diabete group, early diabetic nephropathy group and clinical diabetic nephropathy group. 40 normal cases were regarded as control group. Cyclophorase method was adpoted to determine the quantity of Hcy in serum. Results： The levels of Hcy in early diabetic nephropathy group and clinical diabetic nephropathy group are significantly higher than those of diabete group and normal control group, which has a statistics significance （P〈0.05）. And the level of clinical group is remarkably higher than that of early diabetic nephropathy （P〈0.05）. There are no significant differences between diabete group and normal control group （P〉0.05）. Conclusion： The increased level of serum Hcy is a hint of renal damage in type 2 diabetes patients.