Fas蛋白在妊娠高血压综合征胎盘中的表达及意义

The expression and significance of Fas in pregnancy-induced hypertension's placenta

目的检测妊高征胎盘的Fas蛋白表达水平,探讨妊高征的发病机制。方法采用免疫组织化学方法结合病理图像分析技术,定量分析10例正常妊娠组与30例妊高征组胎盘Fas蛋白表达。结果Fas蛋白主要表达与胎盘绒毛滋养细胞的胞膜及胞浆内。与正常妊娠组比较,妊高征组胎盘Fas蛋白表达显著增加,轻度、中度、重度妊高征组比较,有显著性差异。结论胎盘滋养层细胞Fas蛋白表达增加可能是妊高征的发病机制之一,从而为临床治疗妊高征提供新的方向。

Objective Detection of expression of Fas in placenta explores the pathogenesis of pregnancy-induced hypertension. Methods Immunohistochemical staining method with pathological image analysis technology analysis 10 patients with normal pregnancy group of 30 cases of placental pregnancy induced hypertension group in trophoblast cells＇ expression. Results expression of Fas mainly lies in placental trophoblast cells＇membrane and the cytoplasm. With the normal pregnancy, expression of Fas in placenta increased significantly, mild, moderate, severe pregnancy induced hypertension group, so the difference was significant. Conclusion Increase of the expression of Fas in trophoblast cells is the pathogenesis of PIH so as to provide a new direction in the clinical treatment of PIH.