肾上腺髓质素在上皮性卵巢癌中的表达及意义

Expression and significance of adrenomedallin in Epithelial Ovarian Carcinoma

目的探讨肾上腺髓质素(adrenomedullin,AM)在上皮性卵巢癌中的表达及其临床意义。方法选取蜡块包埋标本,正常卵巢组织10例、卵巢上皮性良性肿瘤10例及上皮性卵巢癌50例,采用免疫组织化学S-P法检测AM蛋白的表达,并结合临床资料进行分析。结果AM在上皮性卵巢癌组织中的阳性表达率(74%)明显高于正常卵巢组织(20%)及卵巢上皮良性肿瘤组织(30%),差异具有统计学意义(P<0.05);在正常卵巢组织和卵巢上皮性良性肿瘤组织中的表达差异无统计学意义(P>0.05)。AM的表达与病理分级有关(P<0.05),而与年龄、临床分期及组织学类型无关(P>0.05)。结论AM在上皮性卵巢癌组织中的表达明显高于正常卵巢组织及卵巢上皮性良性肿瘤组织,且与病理分级相关,提示AM与卵巢癌的发生发展有密切关系,是反映卵巢癌恶性程度和侵袭性的重要指标。

Objective To investigate the expression of adrenomedullin（AM） protein in human epithelial ovarian carcinoma and its clinical significance. Methods Selected wax lumps including 10 ovarian normal tissue , 10 epithelial benign ovarian tumor and 50 epithelial ovarian carcinoma. The expression of AM were examined by the immunity organization S-P method, and the relationship between the expression of AM and patient clinical pathologic parameters was aggregate analyzed. Results The expression of AM in epithelial ovarian carcinoma （74.0%） was much higher than that in normal ovarian tissue（20. 0% ） and benign ovarian neoplasm （30. 0% ）, the difference was statistically significance（P 〈 0. 05 ）. The expression of AM was correlated with pathologic classification （ P 〈0. 05 ）, but not with age,clinical stage and histological types （ P 〉 0. 05 ） . Conclusion The Expression of AM in epithelial ovarian carcinoma was significantly higher than that in normal ovarian tissue and benign ovarian neoplasm. It was in contact with pathologic classification. AM had close concern in occurrence and development of ovarian carcinoma. It played a key role in the progression and metastasis of epithelial ovarian carcinoma.