不同时机应用格拉司琼对预防全身麻醉术后恶心呕吐的影响

Influence of granisetron using in different time to prevent postoperative nausea and vomiting in patients undergoing general anesthesia

目的探讨不同时机应用格拉司琼对预防全身麻醉术后恶心呕吐的影响。方法选择择期气管插管全身麻醉手术的患者48例,按应用格拉司琼的不同时间将患者随机分为三组:A组:麻醉诱导完毕即刻;B组:麻醉诱导完毕后1h;C组:术毕拔出气管导管后。记录术后24h内恶心呕吐的发生情况。结果术后恶心发生率及术后呕吐发生率在A组与B组间比较差异均无统计学意义(P>0.05)。C组的术后恶心发生率及术后呕吐发生率明显低于A组与B组(P<0.05)。结论格拉司琼在预防术后恶心呕吐时,建议在术毕应用。

Objective To observe the different effects of granisetron using in different time to prevent postoperative nausea and vomiting in patients undergoing general anesthesia. Methods 48 patients undergoing general anesthesia were selected, and they were randomly divided into three groups by the different time of granisetron using, 3 mg granisetron was injected at the moment of the general anesthesia inducing in group A, and after 1 h in group B, then after tracheal tube drawing time in group C. The episodes of nausea and vomiting were recorded during 24 hours after operation. Results No significant differences were observed in the terms of nausea and vomiting between group A and B（P 〉0.05）. The rates of nausea and vomiting in group C were lower than in group A and B （ P 〈 0.05 ）. Conclusion Granisetron should he used at the moment of tracheal tube drawing time to prevent postoperative nausea and vomiting in patients undergoing general anesthesia.