CA125和AFP检测对原发性肝癌诊断的分析

The differential expression of CA125 and AFP in primary liver cancer

目的分析CA125和AFP在原发性肝癌患者血清中的表达情况。方法采用放射免疫法分析对63例原发性肝癌患者进行血清CA125和AFP的检测,统计分析两项指标的表达情况,并进行比较。结果CA125和AFP的含量分别为(172.8±200.5)ku/L,(262.4±286.3)ug/L.以CA125>35ku/L,AFP>20ug/L为原发性肝癌诊断标准,其阳性率分别为69.18%和68.13%,两者联合检测阳性率为87.3%。统计学Ridit分析,两者表达阳性率差异无统计学意义,相关性分析,两者无线性相关关系存在。CA125和AFP单项检查的阳性率分别与联合检查的阳性率进行χ2检验,差异均有统计学意义(P<0.05)。结论CA125是一项较好的原发性肝癌诊断标志物,与AFP阳性率差异无统计学意义,与AFP无相关性。联合检测可显著提高诊断阳性率。

Objective To analyze the expression of CA125 and AFP in primary liver cancer. Methods Immunoradio metric assay and statistical analysis was used to quantify the levels of CA125 and AFP in the serum of 63 case of primary liver cancer patient. Results The quantify of CA125 and AFP were （ 172.8 ± 200. 5 ）ku/L and （262.4 ± 286.3 ）ug/L. If CA125 〉 35 ku/L , AFP 〉 20 ug/L was diagnostic level , the positive rates in primary liver cancer of CA125 and AFP were 69.5 % and 68.3 % , the positive rates of combination CA125 and AFP was 87.3 %. Used Ridit analysis , the positive rates of CA125 and AFP were not statistic significance ;used correlation analysis , CA125 and AFP were not linear correlation. Usedx2 analysis , The positive rates of CA125 or AFP has statistic significance with the positive rates of combination. Conclusions CA125 is a good tumor mark of primary liver cancer , not statistic significance with AFP , and combination AFP can have higher positive rates in primary liver cancer.