强心冲剂对心衰家兔模型心钠素、血管紧张素Ⅱ的影响

Effect of Cardiotonic Granules on ANP and AngⅡ of Rabbit Model of Heart Failure

目的:观察中药复方制剂强心冲剂干预后心衰家兔模型心钠素(ANP)、血管紧张素Ⅱ(AngⅡ)的变化,探讨该复方制剂对神经内分泌活性的影响。方法:采用腹主动脉缩窄术建立家兔心衰模型,予强心冲剂和地高辛灌胃给药,9日后颈动脉取血,检测并比较ANP、AngⅡ的活性。结果:心衰模型家兔ANP、AngⅡ活性显著升高,释放失衡,强心冲剂干预后可以纠正其失衡状态,明显降低ANP、AngⅡ水平。结论:强心冲剂能显著纠正神经内分泌激素释放失衡状态,改善神经内分泌激素的激活,防止心衰的进一步恶化。

Objectives：Changes in ANP and Ang Ⅱ of rabbit model of heart failure were observed after the intervention of Cardiotonic Granules, a compound Chinese medicine preparation, and the preparation＇ s effect on neuroendocrine activity was investigated. Methods： Rabbit model of heart failure was established by abdominal aorta coarctation, and intragastrically administered with Digoxin or Cardiotonic Granule respectively. On day 10,blood taken from carotid were detected to study activity of ANP and Ang Ⅱ. Results：in heart failure model,the activity of ANP and Ang Ⅱ rose significantly and the release disproportionately increased. The intervention of Cardiotonic Granules rectified the imbalance by bringing down levels of ANP and Ang Ⅱ remarkably. Conclusion： Cardiotonic Granules can rectify imbalanced release of neuroendocrine hormones, and inhibit the hyperactivity, therefore, prevent aggregation of heart failure.