肾透明细胞癌的COX-2表达与MSCT征象的相关性研究

Correlation between COX-2 Expression and Multi-slice Spiral CT Manifestations in Renal Clear Cell Carcinoma

目的:探讨肾透明细胞癌(CRCC)的COX-2表达及其与MSCT征象之间的关系。方法:搜集经手术病理证实且术前有详细的MSCT资料的32例CRCC患者的石醋包埋切片及10例正常肾组织切片,采用免疫组化S-P法检测每例受检者COX-2的表达情况。观察MSCT图像上肿瘤大小,有无液化、坏死、囊变,肿瘤边界,平扫及各期增强扫描时肿瘤密度,肿瘤最大强化程度,肾静脉或/和下腔静脉有无受侵,邻近或/和远处器官有无转移等,并分析MSCT征象与COX-2表达水平的相关性。结果:CRCC组中COX-2表达明显高于正常组(P<0.01);COX-2表达与MSCT图像上肿瘤大小,最大强化程度,有无液化、坏死、囊变,肿瘤边界.肾静脉或/和下腔静脉有无受侵,邻近或/和远处器官有无转移有相关性(P<0.05);与平扫肿瘤密度无相关性(P>0.05)。结论:COX-2表达与CRCC的发生、发展有关.根据CRCC的MSCT表现在一定程度上可以判断CRCC的生物学行为和恶性程度。

Objective： To study the correlation between COX-2 expression and multi-slice spiral CT （MSCT） manifestations in clear renal cell carcinoma （CRCC）. Methods： The MSCT images and pathology materials of 32 CRCC patients were collected. The paraffin embedded histology tissue of these 32 CRCC patients and 10 normal kidney were examined immuno-histochemically using SP technique for COX-2 expression. CT images were evaluated for the size, margin, intra-tumoral necrosis, liquefaction, cystic degeneration, attenuation of pr-/post contrast enhancement at various phases, maximum enhancement of the tumor as well as whether renal vein, inferior vena cava,adjacent or distal organ were invaded. The correlation of MSCT manifestations and the level of COX-2 expression was analyzed. Results：The COX-2 expression of CRCC was significantly higher than that of normal renal tissue （P〈0.01）. The level of COX-2 expression was significantly correlated with the size,maximum enhancement, intra-tumoral necrosis, liquefaction, cystic degeneration and margin of the tumor, as well as invasion of renal vein or/and inferior vena cava, adjacent organs or/and distant metastases manifested on MSCT （P〈0.05） ,but was not related to the attenuation on pre-contrast scan of the tumor （P〉0.05）. Conclusion：The expression of COX-2 had significant relationship with the occurrence and development of CRCC. To some extent, MSCT might predict the biological behavior and malignancy of CRCC.