复方甘草酸苷联合泛昔洛韦治疗带状疱疹疗效观察

Observation on treating herpes zoster with compound glycyrrhiz and famciclovir

目的观察复方甘草酸苷联合泛昔洛韦治疗带状疱疹的有效性和安全性。方法将98例带状疱疹患者随机分成两组。治疗组50例，给予复方甘草酸苷联合泛昔洛韦治疗；对照组48例，给予泛昔洛韦治疗，疗程均1周，用药10d后观察比较两组止疱、结痂、止痛和痊愈的时间及后遗神经痛发生率。结果治疗组与对照组相比，在止疱[（2．38±0．76）d，（2．97±0．89）d]、结痂[（5．15±1．42）d，（6．91±1．97）d]、止痛[（4．06±1．34）d，（6．05±1．83）d]和痊愈时间[（7．32±2．21）d，（9．86±2．77）d]方面差异有统计学意义（均P〈O．05），后遗神经痛发生率两组差异无统计学意义（2％，4．2％）（P〉0．05）。结论复方甘草酸苷联合泛昔洛韦治疗带状疱疹疗效明显优于单用泛昔洛韦。

Objective To observe the efficacy and safety of compound glycyrrhizin and famciclovir in the treatment of herpes zoster. Methods 98 patients with herpes zoster were randomly divided into 2 groups. The treatment group were administrated with compound glycyrrhizin for a week. The control group were administrated with famciclovir for a week. The time of blister stop, crust formation, pain disappearance and cure was observed after 10 days. The rate of postherpetic neuralgia was observed too. Results The difference was significant between treatment group and control group in the time of blister stop [ （ 2.38 ± 0.76 ） d, （ 2.97 ± 0.89 ） d ], crust formation [ （ 5.15 ± 1.42）d,（6.91 ± 1.97）all,pain disappearance[ （4.06± 1.34）d,（6.05 ± 1.83）d] and cure[ （7.32 ± 2.21）d,（9.86 ± 2.77 ）d] （all P 〈 0.05 ）. The difference of the rate of postherpetic neuralgia was insignificant between two groups （2% ,4.2% ）（P〉0.05） .Conclusion Combined therapy of compound glycyrrhizin and famciclovir was safe and effective for the treatment of herpes zoster.