环氧化酶和血管内皮生长因子在子宫腺肌病中的表达及意义

Expression and significance of COX-2 and VEGF in the tissue of adenomyosis

目的探讨环氧化酶2（COX-2）和血管内皮生长因子（VEGF）在子宫腺肌病中异位内膜及在位内膜中的表达及其临床意义。方法应用免疫组织化学法检测COx-2和VEGF在子宫在位内膜、异位内膜和正常内膜中的表达差异。结果（1）COX-2在子宫腺肌病（观察组）异位内膜表达评分（4．62±0．96）、在位内膜中的表达评分（4．59±0．77）与正常子宫内膜组（3．55±1．276）问比较差异有统计学意义（P〈O．05）；异位内膜与在位内膜中COX．2表达差异无统计学意义（P〉O．05）。（2）VEGF在子宫腺肌病（观察组）异位内膜中的表达评分（4．62±0．96）、在位内膜中的表达评分（4．59±0．77）与正常内膜组（4．30±0．81）比较，差异有统计学意义（P〈O．05）。（3）COX．2和VEGF在子宫腺肌病患者异位内膜中的表达呈正相关（P〈O．05）。结论COX-2和VEGF在子宫腺肌病的发生、发展中起着关键性作用，两者在血管生成过程中密切相关，可能为子宫腺肌病的治疗提供新的靶点。

Objective To discuss the expression of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor（VEGF） in adenomyosis and its clinical significance. Methods The expression of COX-2 and VEGF was examined by immunohistochemistry SP method, in ectopic endometrium and eutopic endometrium, compared with normal endometrium. Results （1）COX-2 expression in ectopic, eutopic endometrium with adenomyosis was significantly higher than that in control group（P 〈 0.05）. No statistically significant difference was found between ectopic endometrium and eutopic endometrium group with adenomyosis （ P 〉 0.05 ）. （2） VEGF expressions in ec- topic, eutopic endometrium with adenomyosis were both significantly higher than that of control group（P 〈 0.05）i no statistically significant difference was found between ectopic endometrium and eutopic endometrium group（P 〉 0.05）. （3）COX-2 and VEGF had the positive relativity in the ectopic endometriumal expression of adenomyosis patient（P 〈 0.05）. Conclusion COX-2 and VEGF may play a key role in adenomyosls. Both may have close relation in anglogenesis and may provide new targets for therapy of adenomyosis.