米索前列醇用于足月妊娠引产的临床观察

A comparison of misoprostol and ricnus oil meal for cervical ripening and labor induction

目的探讨米索前列醇用于足月妊娠引产的安全性及效果。方法120例有引产指征的足月妊娠初产妇．随机分为两组，研究组（60例）用米索前列醇50弘g阴道用药．每3小时1次至正式临产；对照组（60例）用蓖麻油鸡蛋餐口服。结果两组引产总有效率差异无统计学意义，研究组引产时间[（12．2±3．5）h]显著短于对照组[（18．1±3．2）h]（P〈0．05），研究组需静脉滴注缩宫素人数为10％，显著少于对照组的40％（P〈0．05），用药6h后研究组评分提高5．5分，对照组提高3．1分，评分结果比较，差异有统计学意义（P〈0．05），研究组子宫收缩过频的发生率为16．7％，对照组为3．0％。结论阴道放置米索前列醇用于足月妊娠引产能促宫颈成熟及发动子宫收缩，是安全、有效的引产方法。

Objective To compare the safety and efficacy of intravaginal prostaglandin E1,misoprostol with ricinus oil meal for labor induction. Methods 120 patients with an indication for induction of labor were randomly assigned to two groups（60 cases each） induction with misoprotol, 50μg intravaginally every 3 hours until active labor,or with that ricinus oil meal was taken. Results The time from start of intuction to vaginal deliery was significandy shorter than in the misoprostol group[ （ 12.2 ± 3.5 ） h vs （ 18.1 ± 3.2 ） hi （ P 〈 0.05 ）, and fewer patients in the misoprostol group required oxytocin augmentation（ 10% vs 40%, P 〈 0.05 ）. The mean change in the Bishop score was significantly higher than in those receiving misoprotol（5.5 vs 3.1, P 〈 0.05 ）. Uterine tachysystole occurred more frequently in patients in the misoprostol group（ 16.7% ） than in the ricinus oil meal group（3.0% ）. No significant difference was noted in the mode of delivery and patients of successful labor induction. Conclusion Vaginally administered misoprostol is an effective agent for the cervical ripening and induction of labor.