鲍曼不动杆菌肺炎37例临床分析

The clinical analysis of the pneumonia caused by aeinetobacter baumannii

目的探讨医院内感染不动杆菌肺炎的临床特点、危险因素及抗生素的敏感性。方法回顾性分析37例鲍曼不动杆菌肺炎患者的临床表现、痰细菌培养及药物敏感试验结果。结果37例不动杆菌肺炎多发生在[CU病房、多数有侵袭性治疗、机械通气患者；亚胺培南、丁胺卡那霉素、哌拉西林／他唑巴坦是较为有效药物，对其他抗菌药物耐药率均较高；死亡5例，泛耐药菌株患者病死率41．7％，明显高于非泛耐药菌株患者（死亡2例，病死率8％）。结论鲍曼不动杆菌是医院重要的多重耐药致病菌，宜根据药敏试验结果选用有效抗生素，对有危险因素者应及时行细菌培养加药敏试验。

Objective To observe the clinical characteristics, risk factors, and sensitivity to antibiotics of nosocomial infections caused by acinetobaeter baumannii. Methods Data were retrospectively collected from all isolated 37 strains acinetobacter. The clinical features, results of suptum culture and test of drug sensitivity were reviewed. Results The 37 acinetobacter baumannii strains mainly distributed in intensive care unit （ICU）, most of them had the risk factors of receiving invasive treatment, mechanical ventilation, ect. The antibiotics imipenem, amikacin,pipercillin/tazobactam showed good efficacy for patients with acinetobacter infection,but other antibiotics had highly drug resistant rate. 5 were dead. The mortality of nosocomial infections caused by multi-drug resistant acinetobacter was 41.7 % ,which was much higher than the non-multi-drug resistant＇s（2 dead, the mortality was 8 % ）. Conclusion Acinetobacter is one of the most important multi-drug resistant pathogen in nosocomial infec- tions. Antimicrobial agents should be chosen according to antimicrobial susceptibility test results. Patients who have the risk factors of nosocomial infections caused by acinetobacter should have suptum culture and antibiotic susceptibility studies as soon as possible.