MR常规序列及弥散成像对肝癌诊断价值的实验研究

An experimental study on the value of MR conventional series and DWI in diagnosis of liver tumor

目的本研究利用兔VX2肝癌模型不同时间在MRT1WI和T2WI及DWI的表现,从而探讨DWI在肝癌诊断中的价值。方法30只新西兰实验兔在CT引导下,采用经皮瘤组织块注射法进行种植制作VX2肝癌模型。分别在种植后第4天、1、2、3周进行MRT1WI、T2WI、T2WISIR和DWI扫描。观察不同MR检查方法在肿瘤肿植后不同时间对肿瘤的检出率。结果30个实验动物,肿瘤种植成功25例,成功率81.25%。种植后第四天各种检查方法即可显示肿瘤灶,DWI、T1WI、T2WI和T2WISPIR和的检出率为别为80%、60%、72%、72%,经统计学分析无显著性差别。第1、2、3周MR各序列检出率均为100%,在种植4天和1周后各检查方法检查率的比较中,DWI没有显著差别,其它检查方法有显著差别。结论DWI是检查肝癌比较敏感技术,受肿瘤血供的影响很小,在肝脏肿瘤的诊断中将得到越来越广泛的应用。

Objective To investigate the values of MR DWI in diagnosing hepatic carcinoma by studying the appearances of rabbit VX2 hepatic carcinoma in MR TIWI, T2WI and DWI series at different tumor transplanted times. Methods The metastatic rabbit VX2 hepatic carcinoma models were presented in thirty New Zealand white rabbits. VX2 carcinoma masses were injected into the liver using percutaneous puncture inoculation method in guiding by CT scanner in each group. MR TIWI, T2WI, T2WI SPIR and DWl were performed in all experimental animals at 4th, 1, 2 and 3 weeks after implantation. The diagnosis rates of different methods in different time were observed and analyzed. Results Of 30 rabbits, 25 were transplanted VX2 hepatic carcinoma. The success rate of carcinoma transplanted was 81.25 %. The tumor locus was found in every examination series at 4th after the implantation. The diagnosis rates of DWl, TlWl, T2Wl and T2Wl SPIR were 80%, 60%, 72% and 72% respectively. No statistical difference was found. The diagnosis rates were 100% in all MR series at 1, 2 and 3 week after implantation. In comparison of diagnosis rates between 4 days and 1 to 3 week after the tumor implantation in different series, the significant difference was only observed on DWl series and no difference on other series. Conclusion MR DWl is a sensitive series in examination of liver tumor, influenced little by tumor blood supply, and will be used in diagnosis of liver tumor more and more.