支气管动脉灌注联合化疗治疗晚期非小细胞肺癌疗效的探讨

Curative effect of bronchial arterial infusion and CT guided percutaneous ethanol injection in advanced non-small cell lung cancer

目的观察支气管动脉灌注化疗联合 CT 引导经皮无水乙醇注射治疗晚期非小细胞肺癌的疗效。方法回顾性分析2004年10月～2005年10月行支气管动脉灌注化疗的晚期非小细胞肺癌患者36例。其中21例联合无水乙醇注射(观察组);15例为单纯灌注化疗(对照组)。结果观察组 CR3例;PR14例;S4例,有效率81%。对照组无 CR 患者,PR9例,S3例,P2例,有效率60%。观察组客观疗效、半年、1年生存率均高于对照组,具有显著性差异。结论支气管动脉灌注联合 CT 引导经皮无水乙醇注射治疗晚期肺癌,疗效好,无严重并发症。

Objective To observe the therapeutic effect of chemotherapy combined bronchial arterial infusion （BAI） with CT guided percutaneous ethanol injection （PEI） in advanced non small cell lung cancer （NSCLC）. Methods Data of 36 cases with NSCLC treated by BAI from Oct, 2004 to Oct, 2005 were retrospectively analyzed. Among them, 21 cases were also treated by PEI （group A）. 15 cases received BAI only （group B）. Results The efficient rate was 81% for group A （3 CR, 14 PR and 4 S） and 60% for group B （no CR, 9 PR, 4 S, 2 P ）. Significant difference developed between group A and group B in efficient rate and half or one year survival rates, with group A higher than that of group B. Conclusion Combining interventional therapy of BAI and PEI showed good therapeutic effect in the treatment of advanced lung cancer, without severe side-effect.