骨髓间充质干细胞移植在心脏再生医学中的研究进展

Current situation of bone mesenchymal stem cell transplantation in cardiac regeneration

随着干细胞组织工程医学的进展,干细胞移植治疗心脏疾病尤其是缺血性心脏病的研究已经积累了大量的基础研究数据,但就移植细胞选择、移植时机、移植细胞数量、移植后细胞的分化、再生能力及旁分泌作用等尚有较多争议,而对其相关分子机制及与基因组织工程、临床药物相互影响等的研究更是处于起步阶段。大量的资料表明骨髓间充质干细胞(BMSCs)在心脏再生医学中有独特优势,本文将重点讨论BMSCs移植在心脏再生医学中的研究进展,并就其与基因工程、组织工程和临床药物联合应用加以探讨。

The accumulating data of basic researches and clinical trials have proved that stem cell transplantaion is effective on improving heart function in the treatment of heart diseases, especially isehemie heart disease. There are still intensive controversies regarding ideal cell type and cell number, the juncture for transplantation, the differentiation and regeneration capacity, and the effects of paraerine after transplantation. And the researches on the molecular mechanism of the cell therapy, the combination with gene engineering or clinical medicine are still at early stage, A great deal of data indicated that bone mesenehymal stem cells （BMSCs） are with advantageous for cardiac regeneration, These cells can improve cardiac function significantly after transplanted into the damaged heart. BMSCs transplantation may be involved in the myogenesis, angiogenesis, inhib- iting apoptosis of myoeytes, improving remodeling of heart and the secretion of many beneficial eytokines. In this review, we focused on researches on BMSCs in cardiac regeneration and introduced the combined treatment of BMSCs transplantation with gene engineering, tissue engineering and clinical medication.