洛赛克预防脑出血昏迷并发应激性溃疡出血的临床观察

Clinical observations on the thrapeutic effect of losec in preventing cerebral hemorrhage and coma complicated by bleeding stress ulcer

目的观察洛赛克预防脑出血并发应激性溃疡出血的疗效。方法随机将72例脑出血昏迷患者分为静脉应用洛赛克组、西米替丁组及胃管注入洛赛克片剂(胶囊)组3组。全部患者置入胃管抽取胃液测量用药前后持续7 d的pH值及潜血反应。结果胃液pH值由用洛赛克前1.35±0.70经用药后升至5.03±0.76(P<0.01);洛赛克静脉注入组与胃管注入组2组比较差异无显著性(P>0.05),洛赛克2组与西米替丁组比较差异有非常显著性(P<0.01)。洛赛克静脉注入与胃内注入预防脑出血应激性溃疡出血疗效一致,总有效率均为91.67%;应用西米替丁组有效率则为66.67%,2组比较差异有显著性(P<0.05)。结论洛赛克能有效地预防脑出血并发应激性溃疡出血。

Objective To observe the therapeutic effect of losec in preventing cerebral hemorrhage complicated by bleeding stress ulcer. Methods Seven-two cases of cerebral hemorrhage and coma were randomly divided into 3 groups ： （ 1 ） Intravenous drip of losec; （2） Administration of losec by gastrogavage; （3） Intravenous drip of cimetidine. The gastric juice was drawn from all of the patients to measure a week＇s successive pH value and the occult blood reaction before and after administration of the drugs. Results pH value of the gastric juice increased from 1.35 ± 0.70 （ before administration losec） to 5.03 ± 0. 76 （ P 〈 0.01 ） （after）. There was no significant difference between the first and second groups （ P 〉 0.05 ）. Comparison of the first and the second groups with the third group was P 〈0. 01. The therapeutic effect of the first group was the same as the second group. The total effective rate was 91.67%. The effective rate of the third group is 66. 67%. The ratio between the two groups was significant （ P 〈 0. 05 ）. Conclusion Losec can effectively prevent cerebral hemorrhage complicated by bleeding stress ulcer.