胃泌素表达与大肠肿瘤的发生和细胞增殖的关系

Relationship between gastrin expression, and development of colorectal neoplasm and cell proliferation.

目的探讨胃泌素表达与大肠肿瘤的发生和细胞增殖的关系。方法应用免疫组化技术检测15例正常大肠组织、21例大肠腺瘤和70例大肠癌组织中胃泌素及Ki67的表达。结果在正常大肠黏膜、大肠腺瘤和大肠癌组织中，胃泌素的阳性表达率依次为0、28．6％和25．7％，大肠癌和腺瘤组显著高于正常对照组（均P〈0．05），肠癌和腺瘤组比较差异无统计学意义（P〉0．05）；Ki67的阳性表达率依次为40．0％、76．2％和82、8％，大肠癌和腺瘤组中的表达均高于正常大肠组织（均P〈0．05），而肠癌和腺瘤组之间比较差异无统计学意义（P〉0．05）。胃泌素与Ki67之间具有相关性（P〈0．05）。结论胃泌素和Ki67在大肠肿瘤中的表达均增高，胃泌素在大肠肿瘤的发生发展中可能起着重要作用，并且胃泌素可能有增强肿瘤细胞增殖活性的作用。

Objective To investigate the relationship between gastrin expression and the development of colorectal neoplasm and cell proliferation. Methods 15 samples of normal colorectal mucosal tissue,21 samples of colorectal adenomas and 70 samples of colorectal cancer were selected for evaluation of the expression of gastrin and Ki67 with immunohistochemical method. Results In normal colorectal mucosal tissues, colorectal adenomas and colorectal cancer, the positive rates of gastrin expression were 0,28.6% and 25.7 % , respectively, which were significantly higher in colorectal cancer and adenomas groups than in the normal colorectal mucosal tissues （ P 〈 0.05 ）. But there was no significance between colorectal cancer and adenomas （ P 〉 0.05 ）. The positive expression rate of Ki67 with the obove samples were 40.0% ,76.2% and 82.8% , respectively, with statistical results identical with results of gastrin（ P 〈0.05 ）. There was significant correlation between gastrin and Ki67 （ P 〈 0.05 ）. Conclusion Gastrin and Ki67 are highly expressed in colorectal neoplasm. Gastrin might play an important role in the carcinogenesis and development of colorectal neoplasm ,and might promote tumor cell proliferation.