氯沙坦与氢氯噻嗪复方制剂治疗老年轻中度高血压的临床观察

Clinical observation of Losartan and Hydrochlorothiazide compound preparation in patients with mild to moderate essential hypertension

目的比较氯沙彬氢氯噻嗪复方制剂与氯沙坦单剂治疗老年轻中度高血压的疗效与经济学评价。方法分为导入期2周和治疗期8周。共入选99例轻中度原发性高血压患者，随机分为两组：复方制剂组50例，单剂组49例；分别给予氯沙坦50mg/氢氯噻嗪12．5mg复方片剂和氯沙坦50mg片剂每日1次治疗；治疗4周末时血压控制不满意者[坐位舒张压（SeDBP）≥85mm Hg]随后4周分别增加氯沙坦50mg。结果治疗2、4和8周后，复方制剂组与单剂组收缩压和舒张压均明显降低（均P〈0．01）；两组降压的总有效率相同，但是两组的显效率和有效率差异有统计学意义（均P〈0．05）。结论复方制剂与单剂相比，能更快更显著降低收缩压和舒张压。对于需要两种或两种以上药物治疗的患者，复方制剂服药更方便，依从性更好。药物的效价比更好。

Objective To compare therapeutic effect of Losartan and hydrochlorothiazed compound preparation and Losartan in patients with mild to moderate hypertension and to conduct economical evaluation. Methods The trial began with 2 weeks lead-in period and followed by 8 weeks therapy. 99 cases of mild to moderate hypertension were randomly divided into two groups ： compound preparation group （ n = 50 ） and Losartan （ n = 49 ）. The patients were given Losartan 50 mg/h ydrochlorothiazed 12.5 mg compound preparation and Losartan 50 mg , once a day . If the SeDBP ≥ 85 mm Hg at 4th week, Losartan was added to 50 mg. Results After two, four and eight weeks treatment, systolic blood pressure and diastolic decreased obviously（P 〈 0.01 for each ） ;The overall effective rate of of antihypertension was the same in both groups, but the different ratio of availability and validity in two groups was significant （ P 〈 0.05 for each ）. Conclusion Losartan/hydrochlorothiazed compound preparation has significant advantage in improving both systolic and diastolic pressure compared with monotherapy of Losartan. In addition, the patients receiving compound preparation are well tolerated ,with higher compliance.