摘要
目的探讨腺苷预处理对行法洛四联症（TOF）根治术婴幼儿的脑保护作用。方法将120例体外循环下行TOF根治术婴幼儿随机分为腺苷组和对照组，腺苷组在术前静脉滴注腺苷，总量为1.5mg／kg。分别于转流前及开放循环后30min、12h取静脉血，采用ELISA法测定血浆中神经组织蛋白质S-100β（S-100β蛋白）、神经元特异性烯醇化酶（NSE）水平。结果腺苷组主动脉开放后30min、12hS-100β为（0．346±0．162）和（0．541±0．272）μg／L，明显低于对照组（0．717±0．260）和（1．140±0．567）μg／L（均P〈0．001）；腺苷组NSE为（10．43±5．54）和（15．54±7，98）μg／L，明显低于对照组（15．75±7．96）和（23．67±8．00）μg／L（均P〈0．001）。结论腺苷预处理可以降低TOF根治术婴幼儿血中S-10013和NSE，对脑组织具有良好的保护作用。
Objective To investigate the brain protection of adenosine preconditioning in infants with tetralogy of Fallot C TOF） undergoing open heart surgery. Methods 120 patients with TOF undergoing open heart surgery were randomly divided into two groups ： adenosine group and control group. Total dosage of 1.5 mg/kg adenosine was intravenously dripped in the adenosine group before the cardiopulmonary bypass, Serum S-100β and neurone specific enolase C NSE） were measured before the cardipulminary bypass, 30 min and 12 hours after the aorta off clamping. Results At 30 min and 12 hour after opening the aorta, the S-100β[ （0.346 ±0, 162） μg/L vs. （0.717 ± 0.260）μg/L and （0,541 ± 0,272 ）μg/L vs. （ 1,140 ± 0.567 ） μg/L,P 〈 0,001 ] and NSE [ （ 10, 43 ± 5.54） μg/L vs, （ 15.75 ±7.96） μg/L and （15.54 ±7.98）μg/L vs. （23, 67 ±8.00）μg/L,P 〈0.001 ]were both lower in adenosine group than that in control group. Conclusion Adenosine preconditioning can reduce the S-100β and NES in infants with TOF undergoing open heart surgery and has brain protection.
出处
《中国综合临床》
北大核心
2008年第8期749-750,共2页
Clinical Medicine of China
基金
基金项目：河北省科技厅技术攻关项目（052761246）
