骨桥蛋白在卵巢上皮癌组织和血清中的表达及其意义

Study of the expression of osteopontin in epithelial ovarian cancer tissue and serum

目的探讨骨桥蛋白在卵巢上皮癌组织和血清中的表达及意义。方法分别应用免疫组化和ELISA法测定64例卵巢上皮癌患者卵巢组织和血清中骨桥蛋白的表达水平，并与20例卵巢良性肿瘤和10例正常对照患者卵巢组织中的表达水平进行比较。结果卵巢上皮癌患者卵巢组织和血清中骨桥蛋白的表达水平均与疾病临床分期及病理分化程度有关（均P〈0．01）。骨桥蛋白在卵巢上皮癌组织中的阳性表达率明显高于卵巢良性肿瘤及正常卵巢组织（均P〈0．01）。结论骨桥蛋白与卵巢上皮癌的发生、发展密切相关。

Objective To study the expression and signficance of the osteopontin （ OPN ） in epithelial ovarian cancer tissue and serum. Methods Immunohistochemistry method and ELISA were used to detect the expression of OPN in 64 cases of epithelial ovarian cancer tissue and serum, 20 cases of ovarian benign tumors and 10 cases of ovarian nomal tissues. Results The OPN expression was associated with the clinical staging and histological grading of epithelial ovarian cancer tissue and serum（P 〈 0. 01 ）. The level of OPN in epithelial ovarian cancer tissue was significantly higher than that in benign ovarian tumor and normal control groups （ P 〈 0.01 ）. Conclusion OPN is remarkably correlated with the carcinogenesis and the development of epithelial ovarian cancer.