摘要
目的研究脆性组氨酸三联体（FHIT）、垂体肿瘤转化基因-1（PTTG-1）在分化性甲状腺肿瘤中表达及其与病变的关系。方法应用免疫组化方法检测96例原发性甲状腺肿瘤[腺癌56例（腺癌组），腺瘤40例（腺瘤组）]标本中FHIT、FTTG-1表达。结果FHIT蛋白在腺癌表达显著低于腺瘤（P〈0．01），PTTG-1在腺癌表达高于腺瘤（P〈0．01）。分化性甲状腺癌中癌转移23例与非转移33例、高预后指数（≥65）与低预后指数（〈65）中FHIT（P〈0．01，P〈0．05）、PTTG-1蛋白（P〈0．05，P〈0．01）表达均有统计学意义。结论检测FHIT及PTTG-1水平对于鉴别原发性甲状腺肿瘤良恶性具有重要参考意义，其表达水平可能是判断甲状腺癌预后的观测指标。
Objective To study the relationship between fragile histidine traid （FHIT）, pituitary tumor transforming gene-1 （ PTTG-1 ） in thyroid tumor tissue. Methods The expression of FHIT and PTTG-1 were detected by immunohistochemistry in 96 cases （56 carcinoma,40 adenoma ）. Results Compared with thyroid adenoma, the expression of FHIT decreased （ P 〈 0.01 ）, PTTG-1 increased in thyroid carcinoma（ P 〈 0.01 ）. The expression of FHIT is different in thyroid carcinoma in cancerometastasis to non-cancerometastasis （ P 〈 0.01 ） , prognosis index （≥65） and prognosis index（ 〈 65） （P 〈 0.01 and P 〈 0.05） ; There also was statistically significant differences between the expression of PTTG in thyroid carcinoma （ P 〈 0.05 and P 〈 0.01 ）. Conclusion FHIT and PTTG-1 may be an important reference significance in the differentiation of benign and malignant thyroid tumor tissue, and may serve as useful prognostic markers.
出处
《中国综合临床》
北大核心
2008年第8期780-782,共3页
Clinical Medicine of China
