微创手术加氯丙嗪治疗重度高血压脑出血疗效观察

Observation of therapeutic effect of minimally invasive surgery combined with wintermine in treating severe hypertensive cerebral hemorrhage

目的探讨重度高血压脑出血的有效治疗方法。方法将102例重度高血压脑出血患者随机分为2组，A组行微创手术治疗，于微创术后给予氯丙嗪25mg加入5％葡萄糖溶液250～500ml中静脉滴注，持续1～5d；B组仅行微创手术治疗；同期住院内科治疗的重度高血压脑出血患者55例作为对照（C组），对3组患者生活质量及病死率进行比较。结果A组存活者生活质量明显优于B、C组（P〈0．05或0．01），病死率也明显低于B、C组（P〈0．05或0．01）。结论微创手术联合氯丙嗪静脉滴注治疗重度高血压脑出血病死率低且并发症少。

Objective To study the effective treatment for severe hypertensive cerebral hemorrhage. Methods 102 cases of severe hypertensive cerebral hemorrhage were randomly divided into two groups ： One group with minimally invasive surgery and intravenous drip of wintermine started 1 - 5 days after operation, another only with minimally invasive surgery. The 55 subjects with conservative treatment were selected as control group. Results The quality of life in the survival group was better than in group B and C （ P 〈 0.05, or P 〈 0.01 ）, the mortality of group A was also significantly lower than the other two groups （ P 〈 0, 05, or P 〈 0.01 ）. Conclusion Minimally invasive surgery combined with intravenous drip of wintermine can be a safe and effective method for severe hypertensive cerebral hemorrhage.