摘要
目的：探讨卵巢子宫内膜异位症及子宫内膜样癌中PTEN蛋白表达及其临床意义。方法：采用免疫组织化学S—P法检测20例正常卵巢组织及正常子宫内膜、32例卵巢子宫内膜异位囊肿、25例卵巢子宫内膜样癌中PTEN蛋白的表达。结果：PTEN在卵巢子宫内膜异位症细胞的表达与正常子宫内膜细胞及正常卵巢组织中的蛋白表达相比差异无显著性（P〉0．05）；卵巢内异症Ⅰ-Ⅱ期阳性表达率明显高于Ⅲ-Ⅳ期（P〈0．05）；卵巢子宫内膜样癌中PTEN蛋白表达显著低于正常卵巢及卵巢内异症（P〈0．05）。结论：在卵巢内膜异位组织中，PTEN蛋白表达缺失可能参与了其恶变，有可能成为一个很有潜力的诊断指标及新的治疗靶点而应用于临床。
Objective： To investigate the expression and clinical significance of PTEN in ovarian endometrioma and endometrioid carcinoma. Methods： The expression of PTEN was evaluated by immunohistochemical staining in tumor specimens of normal endometrial tissue （n =20）, normal ovarian tissue （ n = 20）, ovarian endometrioma （ n = 32） ; ovarian endometrioid carcinoma （ n = 25） . Results： There was no significant difference in the expression of PTEN protein between ovarian endometrioma and normal ovarian tissues and normal endometrial tissue （ P 〉 0. 05 ） . Expression of PTEN was negatively correlated with clinicopathological staging of ovarian endometrioma （ P 〈 0. 05） . The expression of PTEN was significantly lower in ovarian endometrioid cancer than the one in ovarian endometrioma （P 〈 0. 05） . Conclusion： PTEN plays a role in the aggravated progression of and may be a potent biodynamic criteria and a novel molecular target for clinical therapy.
出处
《中国妇幼保健》
CAS
北大核心
2008年第22期3171-3172,共2页
Maternal and Child Health Care of China
