1,11-脱氯-6-甲基-4'-去甲基蝴蝶霉素的合成

Synthesis of 1,11-Dechloro-6-methyl-4'-demethylrebeccamycin

2,3-二(1H-吲哚-3-基)-N-甲基马来酰亚胺在三氟乙酸作用下形成吲哚啉中间体,与不经保护的葡萄糖发生糖基化反应,氧化后得到1,11-脱氯-6-甲基-4'-去甲基蝴蝶霉素,总收率约为69%。

1,11-Dechloro-6-methyl-4＇-demethylrebeccamycin was synthesized from 2,3-bis （1H-indol-3-yl） -N-methylmaleimide in the presence of trifluoroacetic acid to give the indoline intermediate, which was subjected to glycosylation with unprotected glucose and then oxidation with an overall yield of about 69%.