树枝状大分子用于药物载体的研究进展

Research progress of dendrimers as drug delivery carriers

树枝状大分子是近年来出现的一类新型合成纳米高分子,具有可控的三维高度支化结构、表面分布着大量的功能基团和单分散等特点,使其在生物医学等领域中日益受到广泛关注。作为一种新型非生物载体,树枝状大分子内部空腔和表面功能基团均可与药物复合,在药物输送和基因转运等方面具有广阔的应用前景。

Dendrimers are a kind of new type synthetic nano-sized macromolecules in recent years. It has characteristics of monodisperse, highly branched three-dimensional with accurately controlled structures, and a large number of controllable peripheral functional groups. So their potential applications in pharmaceutical and biomedical chemistry particularly were regarded increasingly. As a kind of new type non-biology carriers, all interactions between drugs and dendrimers which include lumen and surface functional groups were reviewed. In addition, their application prospect in drug delivery system and the use as gene transfer agent were also discussed.