复方首乌颗粒治疗高脂血症的临床观察

Clinical observation of Compound Shouwu Granule on hyperlipemia

目的:观察复方首乌颗粒治疗高脂血症疗效。方法:复方首乌颗粒组方:何首乌、山楂、水蛭、葛根,分别用渗漉法提取,每克相当于原药材8.2 g。每日2次,每次2 g。6周为1疗程,连续服用2个疗程,并比较给药前后患者血清总胆固醇(TC)、甘油三脂(TG),高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的变化。结果:治疗6周后与治疗前比较血脂有明显下降,至12周时TC下降38.4%,TG下降80.8%,HDL-C升高91.3%,LDL-C下降30.9%(P<0.01)。结论:该制剂有明显降脂作用,对降低冠心病及心肌梗死的发生率有积极意义。

AIM ： To observe the curative effect of Compound Shouwu Granule on hyperlipemia. METHODS ： Compound Shouwu Granule was composed of Radix Polygoni multiflori, Fructus, Crataegi Hirudo, Radix Puerariae, Lobatae, etc. the herbs were extracted with the method of percolation respectively. Each gram of extract equals to 8.2 g original medicine material, to take 2 g, each time, twice a day. Six weeks was one treating course. Patients were treated for two treating course. The changes of total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL-C） s, low density lipoprotein （LDL-C）s, were compared before and after treatment. RESULTS： The blood fat descended obviously after 6 weeks treatment. After 12 weeks, the TC descended by 38. 4%, the TG descended by 80.8%, the HDL-C went up 91.3% , the LDL-C descended by 30.9% （P 〈0.01 ）. CONCLUSION ： The product has the function of declining fat obviously, occurrence rate of decreases of coronary and myocardial infarction.