盐酸环丙沙星的热稳定性和热分解反应动力学研究

Thermal Stability and Thermal Decomposition Kinetics of Ciprofloxacin Hydrochloride

目的:用热分析法分析盐酸环丙沙星的热分解过程及机制。方法:以Al2O3为参比物,在氮气条件下采用差示扫描量热法、热重法和微分热重法分析样品,根据热重曲线数据计算出其特征热分解反应表观活化能(E)、指前因子(A)、反应级数n和pk值。结果:E=101.18kJ.mol-1、lnA=26.96s-、n=1、pk=7.01,常温下药品贮存期为2年。结论:用热分析法研究盐酸环丙沙星等固体药物的热分解过程方法简便,结果可靠。

OBJECTIVE： To study the process and mechanism of thermal decomposition of ciprofloxacin hydrochloride （CPLX） . METHODS： With Al2O3 as reference substance, the samples in nitrogen gas were analyzed by differential scanning calorimetry （DSC）, thermogravimetry （TG）, digital thermogravimetry （DTG）. The thermal kinetic parameters including the energy of activation （E）, pre - exponential factor （A）, reaction order （n） and pk value were computed based on the data of the thermal analysis curves. RESULTS： The thermal kinetic parameters were as follows： E = 101.18 kJ · mol^-1, lnA = 26.96 s- , n = 1, and pk = 7.01, and the storage life of ciprofloxacin hydrochloride under normal temperature was 2 years. CONCLUSION： The thermal analysis method is simple and the result is reliable in the study of thermal decomposition of ciprofloxa-cin hydrochloride.