乌拉地尔在大鼠小肠的在体灌流吸收研究

In Situ Recirculation of Urapidil In Rat's Intestine

目的:研究乌拉地尔在大鼠小肠上、下部的吸收情况,为开发其缓释制剂提供依据。方法:采用大鼠在体小肠回流实验装置,利用高效液相色谱法分别测定酚红和乌拉地尔的含量。结果:乌拉地尔在大鼠小肠上、下段的吸收速度常数Ka分别为0.269、0.271,t1/2分别为2.6、2.58h,吸收率分别为27.29%、28.26%(P>0.05)。结论:乌拉地尔在大鼠小肠上、下段的吸收率无显著性差异,适合制备缓释制剂。

OBJECTIVE： To study the absorption of urapidil in upper and lower rat＇ s small intestine for reference of developiing sustained release preparation of urapidil. METHODS： The intestine in rats was cannulated for in situ recirculation. HPLC was used to determine the concentrations of phenolsulfonphthalein and urapidil. RESULTS： In upper and lower rat＇s small intestine, Ka（h 1） were 0,269 and 0.271, t1/ 2（h） 2.6 and 2.58, and the percent of absorption 27.29% and 28.26%, respectively （P 〉0.05）. CONCLUSION： There was no significant difference between upper and lower rat＇s small intestine in the percent of absorption of urapidil and which thus suitable to be prepared into sustained release preparation.